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Re: BonelessCat post# 43412

Thursday, 10/10/2013 2:02:03 AM

Thursday, October 10, 2013 2:02:03 AM

Post# of 403061
Yep thanks. Figured that out taking a closer look at the article you posted. Thanks for that. The fact that nobody is publishing ways to figure out mouse to human efficacy and seem to only be using it to calculate safe starting dosage does lend credence to the "it's complicated" model. Will try to see if there is anything that discusses the complexity more formally.

So you were thinking about this over a year ago and resolved that efficacy was too complicated for us to calculate off of the animal model without complex algorithms. Good to hear, but as you know I love to see for myself if I can. Any useful references that taught you about the complexity that goes into modeling efficacy?

Thanks.

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