NanoViricides Inc. (NNVC)

[changes_iv]

"The idea behind DAVEI was to design a molecule that hijacks the virus’s fusion machinery, the tools it uses to attach to and attack a healthy cell, and trick the virus into destroying itself. HIV invades a healthy cell by first attaching via protein “spikes” that then collapse to pull viral and cell membranes together, fusing them and allowing the genetic contents of the virus to enter the healthy cell. The cell is rewired by the viral genetic material into producing more viruses instead of performing its normal function, which, in the case of cells infected by HIV, involves normal immunity. AIDS is the result."

“For lack of a better term, DAVEI ‘tricks’ the virus into ‘thinking’ it is about to infect a healthy cell, when, in fact, there is nothing there for it to infect,” Abrams said. “Instead, it releases its genetic payload harmlessly and dies.”

The DAVEI molecule is comprised of two pieces: Membrane Proximal External Region (MPER) and cyanovarin (CVN) which allows it to attach to both the viral membrane and the protein spike of the virus. This allows DAVEI to make the virus behave as if it's attached to a healthy cell.

If I understand this mechanism correctly, the pop of the virus structure is normal once inside the cell but what is not normal is that when attached to DAVEI the virus is tricked (transfers control to EXIT) to pop open outside a cell where it releases its genetic material and is rendered harmless.

In the case of Nanoviricides, Inc., the virus structure attaches to the nanoviricide, the nanoviricide opens up and the lethal "hidden tails" cover the virus particle lipid coat and destroys it rendering it harmless.

DAVEI may be competition years down the road but once Nanoviricides, Inc. reaches the market and proves to be effective the other may not get too far. Too early to say with certainty though. We will continue with the "transformational technology" of Nanoviricides, Inc., keep an eye on the competition and time will tell if their "wheel" is good enough or better than Nanoviricides, Inc. "wheel". You are vested in the success of Nanoviricides, Inc. like many of us are here, and I believe you have agreed that time is on the side of Nanoviricides, Inc., as the Rolling Stones say,...have a great weekend!