Mesencephalic astrocyte-derived neurotrophic factor
MANF, ARP, mesencephalic astrocyte-derived neurotrophic factor, ARMET
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010] (from NCBI)
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Papers on MANF
Qualitative and quantitative evaluation of derivatization reagents for different types of protein-bound carbonyl groups.
New
Hoffmann et al., Leipzig, Germany. In Analyst, 07 Oct 2013
Among the many reported reagents, 2,4-dinitrophenylhydrazine (DNPH), biotin hydrazide (BHZ) and O-(biotinylcarbazoylmethyl) hydroxylamine (ARP) are the most frequently used.
Transcriptional regulation of mouse mesencephalic astrocyte-derived neurotrophic factor in Neuro2a cells.
New
Kiuchi et al., Gifu, Japan. In Cell Mol Biol Lett, 30 Sep 2013
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a novel type of trophic factor.
Armet/Manf and Creld2 are components of a specialised ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases.
New
Briggs et al., Manchester, United Kingdom. In Hum Mol Genet, 15 Sep 2013
Intracellular retention of mutant matrilin-3 causes ER stress and induces an unfolded protein response (UPR) including the upregulation of two genes recently implicated in ER stress: Armet and Creld2.
Roles of Pro-angiogenic and Anti-angiogenic Factors as well as Matrix Metalloproteinases in Healing of NSAID-Induced Small Intestinal Ulcers in Rats.
New
Takeuchi et al., Kyoto, Japan. In Life Sci, 27 Aug 2013
The healing of these ulcers was significantly delayed by the repeated administration of MMP inhibitors such as ARP-101 and SB-3CT.
Advanced Reduction Processes: A New Class of Treatment Processes.
New
Abdel-Wahab et al., College Station, United States. In Environ Eng Sci, May 2013
These experiments identified the combination of sulfite activated by ultraviolet light produced by a low-pressure mercury vapor lamp (UV-L) as an effective ARP.
ARP2/3 localization in Arabidopsis leaf pavement cells: a diversity of intracellular pools and cytoskeletal interactions.
New
Szymanski et al., West Lafayette, United States. In Front Plant Sci, Dec 2012
Actin filaments do not form spontaneously; instead filament nucleators, such as the evolutionarily conserved actin-related protein (ARP) 2/3 complex, can efficiently generate new actin filament networks when in a fully activated state.
Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure.
Review
Glembotski, San Diego, United States. In J Mol Cell Cardiol, 2011
The subject of this review is the cardiomyokine, mesencephalic astrocyte-derived neurotrophic factor (MANF).
Altered expression of Armet and Mrlp51 in the oocyte, preimplantation embryo, and brain of mice following oocyte in vitro maturation but postnatal brain development and cognitive function are normal.
GeneRIF
Jin et al., Hangzhou, China. In Reproduction, 2011
The change in Armet expression lasted while the change of Mrpl51 disappeared after birth.
Coup d'Etat: an orphan takes control.
Review
Impact
Tsai et al., United States. In Endocr Rev, 2011
Cloning of their cDNAs demonstrated the existence of two distinct but related genes: COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2).
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.
GeneRIF
Permi et al., Helsinki, Finland. In J Biol Chem, 2011
MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury.
GeneRIF
Harvey et al., Baltimore, United States. In Exp Neurol, 2010
Pretreatment with adeno-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats.
Solution structure and dynamics of mouse ARMET.
GeneRIF
Nagata et al., Kyoto, Japan. In Febs Lett, 2010
the solution structure of ARMET
Novel CDNF/MANF family of neurotrophic factors.
Review
Saarma et al., Helsinki, Finland. In Dev Neurobiol, 2010
In this review, we discuss novel evolutionary conserved family of NTFs consisting of two members in the vertebrates, cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF).
Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection.
GeneRIF
Shen et al., Hefei, China. In J Cereb Blood Flow Metab, 2010
These results suggest that cerebral ischemia-induced ARMET expression may be protective to the neurons
A KNOX family TALE.
Review
Tsiantis et al., Oxford, United Kingdom. In Curr Opin Plant Biol, 2009
Recent evidence for direct KNOX regulation by myb-related ARP proteins and epigenetic silencing by polycomb repressive complexes have also shed light on the mechanisms defining KNOX gene expression.
Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Impact
Pollard et al., New Haven, United States. In Nature, 2009
Polymerization of actin filaments directed by the actin-related protein (Arp)2/3 complex supports many types of cellular movements.
Delta traffic takes a sh-Arp turn.
Impact
Schejter, In Nat Cell Biol, 2009
In the Notch pathway, the transmembrane ligand Delta is internalized and then re-established on the surface of signal-sending cells to allow the productive binding and activation of the Notch receptor on neighbouring cells.
The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility.
Impact
Way et al., London, United Kingdom. In Nature, 2009
Taking advantage of this, we have analysed the dynamics of neuronal Wiskott-Aldrich syndrome protein (N-WASP), WASP-interacting protein (WIP), GRB2 and NCK, which are required to stimulate actin-related protein (ARP)2/3-complex-dependent actin-based motility of vaccinia virus, using fluorescence recovery after photobleaching.
Chapter 5. Nuclear actin-related proteins in epigenetic control.
Review
Roy et al., Athens, United States. In Int Rev Cell Mol Biol, 2008
A theme emerging from plants and animals is that in addition to their role in controlling the general compaction of DNA and gene silencing, isoforms of nuclear ARP-containing chromatin complexes have evolved to exert dynamic epigenetic control over gene expression and different phases of multicellular development.
Tropomyosin-based regulation of the actin cytoskeleton in time and space.
Review
Impact
Hardeman et al., Westmead, Australia. In Physiol Rev, 2008
The functional specificity of tropomyosins is related to the collaborative interactions of the isoforms with different actin binding proteins such as cofilin, gelsolin, Arp 2/3, myosin, caldesmon, and tropomodulin.
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