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Review Article
Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and
heart failure
Christopher C. Glembotski
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The SDSU Heart Institute and the Department of Biology, San Diego State University, San Diego, CA 92182, USA
abstract
article info
Article history:
Received 5 August 2010
Received in revised form 1 October 2010
Accepted 4 October 2010
Available online 21 October 2010
Keywords:
Cardiomyokine
MANF
ER stress
Cardioprotection
Hypertrophy
We define cardiomyokines as heart-derived secreted proteins that affect cardiovascular function viaautocrine, paracrine and/or endocrine mechanisms. The subject of this review is the cardiomyokine,mesencephalic astrocyte-derived neurotrophic factor (MANF). The expression of MANF is increased in the
ischemic heart, in part, through activation of ER stress, a condition that drastically impairs the expression and
secretion of most cardiomyokines. This novel function of MANF suggests that it may have important roles in
the ER stressed, ischemic heart. Consistent with this are recent
findings showing that MANF protects against
ischemic damage, and that it is anti-hypertrophic. Accordingly, in light of its function as a potentially secreted
cardiomyokine, MANF has translational potential as a novel therapy for ischemic heart disease.