Sunday, September 15, 2013 10:20:03 AM
United States Patent 8,173,764
Diwan , et al. May 8, 2012
Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers
Abstract
There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.
Inventors: Diwan; Anil (West Haven, CT), Onton; Ann Louise (Fairfield, CT), Tatake; Jayant G. (Sandy Hook, CT)
Assignee: AllExcel Inc. (West Haven, CT)
Family ID: 38287941
Appl. No.: 12/223,052
Filed: January 19, 2006
PCT Filed: January 19, 2006
PCT No.: PCT/US2006/001820
371(c)(1),(2),(4) Date: June 17, 2010
PCT Pub. No.: WO2007/084126
PCT Pub. Date: July 26, 2007
LINK
http://www.patent2pdf.com/pdf/08173764.pdf
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