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jaybe

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jaybe

Re: glass_half_full post# 33949

Monday, 09/09/2013 8:54:46 AM

Monday, September 09, 2013 8:54:46 AM

Post# of 80490
Regarding Pona crossing the BBB...

Most TKI's cross the BBB in fractions of plasma concentrations, Pona crosses in multiples.

See excerpt below from world patent on use of Pona in neurodegenerative diseases, click on 'Description' tab and scroll down near bottom to Table 1.

"Ponatinib was 2.79 times greater in brain relative to blood on an area under the curve (AUC) basis and 2.26 times greater on a the basis of maximum concentration observed (Cmax). The observed elimination half-life was also longer in brain than in blood."

http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2012139027&recNum=6&maxRec=252&office=&prevFilter=&sortOption=Pub+Date+Desc&queryString=FP%3A%28ariad%29&tab=PCTDescription

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