Inovio Pharmaceuticals Inc (INO)

[KR_redondo]

Jeffrey Ulmer is Head of External Research for Novartis Vaccines

-2008-
"There are a lot of potential pitfalls along the way of getting the DNA from a syringe into a cell makinga protein. By the time you count up how many of the plasmids you initially inject versus how many are getting to the right place doing the right thing, it’s an infinitesimally small proportion of what you’ve injected,” Dr. Ulmer says. “Electroporation, alternatively, is a
brute force way of getting DNA past
one of the physical barriers and into
cells,” adds Dr. Ulmer.“It is conceivable
this could be accomplished in humans.”
Adds NCI’s Dr. George Pavlakis: “I
have stated in my public seminars that
for us, electroporation is right now the
gold standard for DNA vaccine delivery, giving us the best result in terms of immunogenicity of DNA vaccines.
When this technology matures, it will
be one of the most competitive for
DNA vaccine delivery.”


Novartis has been on the sideline to see how EP translates into humans, I think they have that answered now.