Amarantus Bioscience Holdings Inc (AMBS)

[zoomboom]

Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases

ARMET also known as MANF which AMBS owns the Patents for.

Multiple Epiphyseal Dysplasia (MED). is another potential Orphan Indication

We demonstrate that Armet and Creld2 are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 is a key disease trigger in MED that could be exploited as a potential therapeutic target.


http://hmg.oxfordjournals.org/content/early/2013/08/22/hmg.ddt383.abstract?sid=17d592a9-ef22-4702-9877-c535b6361d87