Amarantus Bioscience Holdings Inc (AMBS)

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#6 CANCER

Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure
Christopher C. Glembotski, The SDSU Heart Institute and the Department of Biology, San Diego State University, San Diego, CA 92182, USA


"Although there are many studies yet to be carried out, based on our current understanding of MANF structure and function, one would predict it to have therapeutic potential. Due to its potentially broad spectrum of action, a MANF-based therapeutic is predicted to be of high impact. All studies carried out to date that have examined the effects of MANF have demonstrated that it is protective in culture and in vivo. Moreover, this protection has been seen in multiple cell and tissue types, including the ischemic heart and brain, as well as in animal models of neurodegenerative disorders. Additionally, since MANF overexpression decreases proliferation of cultured cancer cells, and decreases cardiomyocyte hypertrophy, a MANF-based cancer therapy is conceivable. "