RespireRx Pharmaceuticals Inc (RSPI)

[enemem]

Metabolic interactions between Cu and Zn are extremely complicated. While the suggestion here is that elevated Zn is associated with AD, Zn is protective against diabetes, where its protective action is due to its role as a substrate for a Cu chelator. Further, in juvenile animals, Zn mediates learning and memory, and is transiently elevated in cells undergoing plasticity. I've tended to think of elevated Zn in AD as a reflection of failed Zn homeostasis, and not as a disease driver.

This isn't my area of expertise though, so take this with a grain of salt.