Entremed (ENMD)

[tborges]

Enmd 2076 in combo with Kevetrin for treatment of esophageal cancer???

"[Aurora kinases and cancer].
[Article in Japanese]
Kimura M, Okano Y.
SourceDept. of Molecular Pathobiochemistry, Division of Disease Control, Gifu University Graduate School of Medicine, Japan.

Abstract
Aurora kinases are highly conserved in eukaryotes and involved in many processes during cell division. Three Aurora kinases have been identified in humans and designated as Aurora-A, -B, and -C. Aurora A regulates centrosome function during M phase through its interactions with various cell cycle regulators including TACC, chTOG, Ajuba, BRCA1, LATS2, and p53. Aurora-B localizes at the kinetochore from G2 to metaphase, and relocates to the midbody after anaphase. Aurora-B plays roles in spindle dynamics, chromosome condensation, and cytokinesis by interacting with many proteins such as INCENP, Survivin, CENP-A, MgcRacGAP, and intermediate filaments. Overexpression of both Aurora-A and -B proteins is frequently observed in various human cancer tissues, and a common coding region polymorphism in aurora-Aaffects the risk of breast or esophageal cancer. Ectopic overexpression of Aurora-A or -B protein leads to aneuploid cells. The cells overexpressing active Aurora A or wildtype Aurora-B are tumorigenic in nude mice.

http://www.ncbi.nlm.nih.gov/pubmed/15675572



http://www.biomedcentral.com/content/pdf/1471-2121-12-13.pdf";