Innovation Pharmaceuticals Inc (IPIX)

[Orion Nebula]

I think there is some relevant info in the link Whooops provided. Click on the link and then look at the gray box on the right and you will see an "also published" # for the patent (CA 1340589C). Click on that and from there you can download a 42 page copy of the old patent, which happens to be the European version. At the top you can click through the pages. Go to page 5. Look at lines 26 and 38. 38 specifically notes psoriasis. Line 26 refers to a set of compounds labeled I that comprise the invention. Now back up to page 4. There you will see three variations of a hydroxy group (line 15) that attach at the R1 site of the molecule shown just above it. It has been 39 years since my college chem classes but "A" would seem to correspond to 23 as listed in the new Purisol patent. I think this may be the problem with 23.

It is kind of amazing that the inventor noted psoriasis in the old patent but never pursued it. If the new patent is granted we can all thank inventor Susan Mary Daluge for apparently being so focused on HIV etc. that it was not pursued. Wow. What a complete gift! Of course there are many more derivatives that Dr. M has pursued but it is pretty clear she thought there was applicability in psoriasis. Maybe this is the real surprise - not that it was just derived from a known molecule but the application was known or at least suspected.