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jellybean

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jellybean

Re: Praveen post# 164592

Monday, 07/29/2013 5:10:49 PM

Monday, July 29, 2013 5:10:49 PM

Post# of 252389
Yes, CC-292 obtained from their purchase of Avila. http://www.celgene.com/pdfs/2011_ASH_AVL-292.pdf

Like Ibrutinib, the drug covalently attaches to C481 of the BTK binding pocket and has an IC50 of <0.5 nm, so highly specific. The drug has very low affinity for other kinases with cysteine in their binding pockets. On paper, the two drugs look very similar.
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