Entremed (ENMD)

[tborges]

One of the big problems with any drug taken orally is the absorption into the bloodstream without significant breakdown before reaching its target. This runs contrary to the digestive process. The current study will take into consideration the food types ingested, or not ingested to maximize the bioavailability of the drug at its intended target.

Several years ago it was determined that drinking grapefruit juice had a negative effect on the activity of statins. And, you may remember that grapefruit juice, at one time, was the mainstay of the “Weight Watchers” diet. It was believed that the acidic nature of the juice inhibited the digestive process. This theory was based upon the fact that the digestive process is initiated by the ingestion of food that increased the pH in the gut.

Bioavailability is a major problem with 2ME taken orally (Endostatin, as well) and was the basis for its reformulation as Panzem and the use of nano-technology.

While it may appear that the current study is an effort to fine-tune drug delivery, importantly, it is another indication that this current group of scientists is interested in dotting the i’s and crossing the t’s to more fully understand the MOA of the drug and maximizing it's effectiveness in clinical trials.