Avid Bioservices Inc (CDMO)

[freethemice]

The evolution of the MOA. It is ridiculous to think that suddenly a new understanding of the MOA has occurred,
the understanding has evolved and matured as more was learned. You can easily track how the thinking about the
MOA has evolved over at least the last 4 years by looking at posters which are on Peregrine's website.
http://www.peregrineinc.com/technology/bavituximab-oncology/mechanism-of-action.html

2010
Phosphatidylserine (PS) on dying tumor cells suppresses dendritic cell activation and inhibits tumor immunity: reversal with PS-­targeting antibody
http://www.peregrineinc.com/images/stories/pdfs/2010_AACR_Poster_PS_Reversal.pdf

2011
Phosphatidylserine-Targeting Antibody Induces Differentiation of Myeloid-Derived Suppressor Cells into M1-like Macrophages
http://www.peregrineinc.com/images/stories/pdfs/aacr_moa.pdf

2012
Targeting of Phosphatidylserine by Monoclonal Antibodies Induces Innate and Specific Anti-tumor Responses
http://www.peregrineinc.com/images/stories/pdfs/sitc_2012.pdf

2013
Phosphatidylserine-targeting antibody reactivates tumor immunity and destroys tumor vasculature in mice
http://www.peregrineinc.com/images/stories/pdfs/yin_aacr.pdf