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jaybe

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jaybe

Re: None

Friday, 06/28/2013 10:21:56 PM

Friday, June 28, 2013 10:21:56 PM

Post# of 80490
"Game Over" for Synribo in CML....

Not that anyone was worried about Synribo, but these results make you wonder why they (Teva via Cephalon via ChemGenex)kept pursuing trials, approval, and sales after Pona data in mid-2011 left absolutely no margin for success.

Results reported June 17th from a study of Synribo(omacetaxine) in CML with 2 or more prior TKI's compared to Pona (PACE):

MCyR of 20% vs. Pona 64%

Grade 3/4 AE's:
Thrombocytopenia 67% vs. Pona 34%
Neutropenia 47% vs. Pona 16%
Anemia 37% vs. Pona 8%

Weaker and more toxic? As HB would say...game over.

http://www.ncbi.nlm.nih.gov/pubmed/23787123
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