Avid Bioservices Inc (CDMO)

[entdoc]

PERSPECTIVE: It was never in the cards for "naked Bavi" to have a significant effect on far-advanced lung cancer. Review: Stage IIIB non-small cell lung cancer has spread to lymph nodes above the collarbone or on the opposite side of the chest as the primary tumor. The cancer may have spread to (a) the main bronchus; (b) lung lining, chest wall lining, or chest wall; (c) diaphragm; (d) heart or the membrane around it; (e) major blood vessels that lead to or from the heart; (f) trachea; (g) esophagus; (h) sternum; and/or (i) carina; and/or (j) there may be one or more separate tumors in any of the lobes of the lung. Part or all of the lung may have collapsed or become inflamed and cancer may have spread to the backbone and/or the nerves that control the diaphragm and larynx (not shown). Stage IV non-small cell lung cancer. The cancer has spread to the other lung, and/or to lymph nodes, fluid around the lungs or heart, and/or other places in the body, such as the brain, liver, adrenal glands, kidneys, or bones. Come on folks. Maybe you have to actually do surgery on large cancers: feel them; cut into them; look at surrounding tissue and blood supply. An injection of a "naked" MAB for such? This is not a setback. More an awakening from a pleasant dream? What about safety? Not even mentioned, but at this point it is assumed that Bavi- is safe. We know it can pack a payload. What about chronic disease states other than cancers?
Alzheimers and rheumatologic (immunologic) diseases? PS technology is here to stay and will require huge infusions of cash. The frontline NSCLC results do not confer a huge premium, but the safety profile is auspicious Don't count PPHM out yet.