The Mother of All Combos...
I know its faint but methinks I hear a call for a '113+Pona+Rida combo for EGFR-resistance in glioblastoma.
"Here, we have identified a transcriptional repressive mechanism by which EGFRvIII regulates PDGFRß, shown that EGFR-inhibited GBMs become PDGFRß-dependent for survival through mTOR-dependent transcriptional de-repression, and showed that abrogation of EGFRvIII and PDGFRß stop tumor growth, providing a strong rationale for combination therapy. These results provide the first clinical and biologic evidence for the concept of RTK “switching” as an EGFR TKI resistance mechanism in GBM, and provide a molecular explanation for how tumors can become “addicted” to a nonamplified, nonmutated, physiologically regulated RTK to evade targeted treatment."
-David Akhavan et al, From May 2013 issue of Cancer Discovery
