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Re: keep_trying post# 128832

Friday, 06/21/2013 1:30:12 PM

Friday, June 21, 2013 1:30:12 PM

Post# of 345969
Keep_trying, you explained it better than I did. There seems to be an optimum where the treatment produces the best separation between the arms and that is not always necessarily with the healthiest patients. To put it the other way, the optimum benefit point of Bavi treatment or some other treatment in terms of MOS separation has to be found in trials. So, looking at the MOS in first line we may get relatively disappointing results in comparison with 2nd line but one can argue that MOS in this case shouldn't be the only way to evaluate the drug. The late separation in KM curve may be very interesting - the real question would be why some patients respond much better to the same treatment than others.
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