7:31AM Derma Sciences announces published research concluded total contact casting is more effective in healing diabetic foot ulcers than other standards of care (DSCI) 13.29 : Co announced that a study published in The Cochrane Collaboration concluded that non-removable, pressure-relieving casts, or total contact casts (TCC), are more effective in healing diabetes-related plantar foot ulcers than removable casts or dressings alone. Derma Sciences is the leading manufacturer and marketer of total contact casting systems, including the technologically innovative TCC-EZ. The Cochrane Collaboration is a group of more than 28,000 healthcare specialists who systematically review randomized trials of the effects of prevention, treatment and rehabilitation as well as health systems interventions.
7:17AM Derma Sciences reports results from DSC127 pharmacokinetic study; DSC127 was not detected in any subject's serum samples at any time point (DSCI) 13.29 : Co announced that all data from the pharmacokinetic (PK) study with 0.03% DSC127 gel has been collected and analyzed. Subjects topically applied 0.03% DSC127 to the wound once each day for 28 days. The mean ulcer area at baseline was 9.5 cm2 (Standard Deviation 11.9 cm2). DSC127 was not detected in any subject's serum samples at any time point, using an assay with a lower limit of quantitation of 0.200ng/mL. Accordingly, no PK parameters could be calculated. All samples were also considered to be non-reactive in an assay for anti-drug antibodies. Study subjects showed no clinically significant changes in clinical chemistry, hematology, and electrocardiograms. The 0.03% DSC127 gel was well tolerated and there were no adverse events or serious adverse events considered related to the study drug, as determined by the Principal Investigator. None of the wounds treated with DSC127 gel deteriorated.
