Sunday, June 02, 2013 12:42:57 PM
From an article by Suresh Gupta entitled "Comprehensive Overview Of Active Electroporation Cancer Trials," published on Seeking Alpha:
"Finally, Scancell, a company on the London exchange, is conducting a Phase I/II study on melanoma which looks especially promising. Plasmid DNA called SCIB1 is being electroporated intramuscularly to stimulate T-cells to attack. This phase II trial includes 30 patients who took different doses of the immunotherapy drug. According to a December Scancell press release:
One patient in the 4mg dose group had a long history of metastatic disease and multiple tumour lesions present at the start of treatment (including several in her lungs), all of which decreased in size or disappeared completely following six months of treatment with SCIB1 except for one abdominal tumour nodule which increased in size and which will be resected. This "differential response" pattern is typical of immunotherapeutic agents and is the first signal that SCIB1 may be having an impact on the course of the disease as well as inducing an immune response.
All patients in this trial had either stage III or stage IV melanoma. Of the four patients in the 2-4mg dose, one remains disease free and three of the four are still alive a year after treatment, despite having late stage cancer. The company was given permission to keep treating these patients for 5 years out, which means that although this trial will officially end in 2017, current results will be available at the end of this year.
Scancell has some very impressive results so far and is seeking a buyer when phase II is complete by the end of this year. Given its impressive results for SCIB1, it may be picked up by a big player. If that happens, shares could skyrocket."
Source:
Comprehensive Overview Of Active Electroporation Cancer Trials
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