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Saturday, 05/25/2013 8:01:19 PM

Saturday, May 25, 2013 8:01:19 PM

Post# of 345997
Send cancer a message via Bavi-Express. Good to see more scientists aboard. Upstream/downstream/mid-stream immune system events in the anti-cancer cascade are fascinating, but let's remember Bavi-Immune is an accidental and relatively recent discovery in the years of Bavi development, due (of course) to immunohistopathology studies in lower animals. Bavi began as a double-armed MAB which was to be one of the most specific targeting agents of its time. Years have passed and Bavi remains the same. Compare it to a vehicle with a special docking site on the space station. "Naked" Bavi-, the Bavituximab now beginning PIII clinical trials was a curiosity, an accidental observation noted when a Bavi missile was put into the body "un-armed". So PPHM has the expertise to carry small molecule anti-cancer agents directly to cancer, docking on cancer endothelial cell "flipped" -PS docking sites. "Naked Bavi was never intended to act alone, but its ability to help confer cancer immunity in second challenge situations, and "upstream" macrophage activation is a welcome adjunct to cancer treatment of all types. Just as "Naked" Bavi- was an accident on the way to the marketplace, it was an unfortunate accident that in dire financial straits, PPHM execs made the decision to pair Bavi- with chemotherapy trials (in India) rather than in conjunction with irradiation therapy. Bavi- + irradiation will almost assuredly work much better than Bavi + chemotherapy. And then there is Bavi- Imaging, another potential blockbuster. And what are about 90% of the posts here about? As mentioned above. It's great to see more scientists contributing here. Good luck to all!
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