I am still very optimistic, but the wait has been rough. I think I expected a faster "ROI" because this is a "diagnostics" technology, which is supposed to be easier to productize than therapeutics. Back in mid-2004, I expected the wait to be measured in months, not years.
That said, I do think we must be nearing a breakthrough in terms of validation and market recognition. If we are still in limbo 6 months from now, I will be very disappointed (although I probably still wouldn't sell unless the news started to sour).