It's easy, start with $1.3B sales for 2017...
That includes 1st line CML, launch of 2nd indication in GIST, and launch year of '113 in ALK R/I.
Then assume profit margin of 50%, divide by 184M shares and you get $3.50 a share net EPS.
Then assume PE of 30, so $105, and discount 25% per year back to 2013, and your get $33 PPS today.
Bob's your uncle.