Biotech Values

[poorgradstudent]

ARLQ / MET

Sorry poorgradstudent but I disagree with you.

That's fine. But the questions you ask and your other concerns are answered in the supplemental data to the paper, along with the related literature on this cell line and on c-Met.

Further, activating c-Met mutations are, by and large, missense mutations or amplifications. I've read of one example of an exon encoding a juxtamembrane region being skipped. None of those would be impacted by your concerns, even if relevant.

As for c-terminal truncations, i'm not sure how numerous those examples are since that would truncate the kinase domain and it would not be an activating mutation.


So is there a super-secret c-Met mutant that isn't captured by the RT-PCR or IP? Possible, but I'd ask you to name it.