Sounds like AGN-150998 [DARPin] simply had insufficient differentiation from Lucentis on efficacy. It’s not a dosing issue per se insofar as AGN tested the two highest-tolerated doses from the phase-1 portion of the study in the phase-2 (randomized, controlled) portion (http://www.clinicaltrials.gov/ct2/show/NCT00775411 ).
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