Avid Bioservices Inc (CDMO)

[freethemice]

Radioactive Bacteria Targets Metastatic Pancreatic Cancer
http://www.sciencedaily.com/releases/2013/04/130422154753.htm
Treating cancer with radioactive bacteria
Three wrongs make a right
http://www.economist.com/news/science-and-technology/21576628-surprising-new-way-kill-tumours-three-wrongs-make-right/print

This is a very interesting story. Reading these articles immediately brought a few things to my mind.
1) Using the radioisotope attached to the bacteria is really just an indirect method of targeting the radioisotope to the tumor since
the immune response eliminated the bacteria elsewhere.
2) Cotara delivers the radioisotope Iodine-131 to the necrotic core of a tumor. So why not just use Cotara for metastatic pancreatic cancer?
3) How about attaching I-131 to bavituximab instead of I-124, as has been done before in imaging studies? I-131 is a beta emitter
(electrons), whereas I-124 emits positrons used for PET imaging.
4) If the problem of treating metastatic pancreatic cancer is that the patients die too quickly for bavi to have much effect then using
I131-PGN635, or Cotara, can instead use their targeting ability to deliver the radioiostope which will immediately start killing the
surrounding tumor.
5) What about using bavi and Cotara together for metastatic pancreatic cancer? They should complement eachother, maybe having a
synergistic effect.