Celsion Corporation (CLSN)

[sdtrond]

My comment on AF's hit piece:

(hello to all, been a long time. GLTA)

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I was an uber-bull here, and am completely out the stock now.

However, your (Sobek's) point is a bit irrelevant. Based on their claimed MOA, it's not a spin-job of "extending RFA treatment beyond 45 minutes." I believe the point here is that the continued application of heat allows two secondary (and oft-forgotten) characteristics of dox to manifest:

* Its cell-killing activity is heightened by heat. Thus it’s even more effective than normal.
* It lowers the temperature of the surrounding tissue. This means heat-activated ablation is more effective, especially in the margin areas that otherwise would not be
completely ablated.

I am still not buying into the story here, but it does not surprise me that a longer ablation time is positively correlated with PFS and OS.

-Trond Hildahl