Fibrin degradation products (FDPs) are the substances left behind when clots dissolve in the blood. This article discusses the blood test to measure these products.
How the Test is Performed
A blood sample is needed. For information on how this is done, see: Venipuncture
The blood is sent to a laboratory. The laboratory specialist will run tests on the blood sample to measure the products that are left behind when blood clots dissolve.
How to Prepare for the Test
Your health care provider may tell you to stop taking certain drugs before the test. Drugs that may increase FDPs include barbiturates, heparin, streptokinase, and urokinase.
Do not stop taking any medicine without first talking to your doctor.
How the Test Will Feel
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the Test is Performed
This test is done to see if your clot-dissolving (fibrinolytic) system is working properly. Your doctor may order this test if you have signs of disseminated intravascular coagulation (DIC) or another clot-dissolving disorder.
Normal Results
The result is normally less than 10 micrograms per milliliter (mcg/mL).
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
The example above shows the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.
What Abnormal Results Mean
Increased FDPs may be a sign of primary or secondary fibrinolysis (clot-dissolving activity) due to a variety of causes, including:
•Abruptio placentae
•Burns
•Congenital heart disease
•Disseminated intravascular coagulation (DIC)
•Hypoxia
•Infections
•Intrauterine fetal death
•Leukemia
•Liver disease (See: cirrhosis)
•Portacaval shunt
•Preeclampsia
•Recent blood transfusion
•Recent surgery that involved a heart and lung bypass pump
•Renal disease (See: kidney failure)
•Septicemia
•Thromboembolic states
•Transplant rejection
•Transfusion reaction
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