First off let me just say.......Anything cannabis related is going to me much healthier than any pharmaceuticals. As loading the body with drugs at a young age is much more harmful than not. Where as I would consider mj related substances to be natural/herbal.
Age of son, and size weight and height? And super smart you say, is he good with numbers? Is he able to perceive body language well at all? Very loving huh, that is amazing :)! Oh, and depending on age, what is his independence like....have a good sense of himself, able to work well alone, social ability? That would help me be able to speculate better. And, don't worry about rambling. Some people enjoy substance more than not ;). Also I can tend to go on and on my self HAHAHA! Anyways.........
Oh And what I meant earlier by raw or slightly processed form is, smoking the plant or basic processes(hash keif butter basic oil). Since you are still getting most of the compounds that way just not the bio carbons. Though with some processes people do get excess chlorophyll as some plant material gets adsorbed by the solvent when using anything but the highest of grades of bud.
Hmm, so you said it moderate not severe. Does he have a classified condition? As I know there are a few different types of ASD's. And next, I would then have to ask you on which way you are thinking of, or would plan to medicate him?
As far as the compound Thc goes, higher amounts in frequent doses over long periods of time are not to good for certain mental conditions or physios IMO. Though when you have low thc and high cbd, or even just concentrated cbd by its self it has different properties. As it has been proven that cbd has it's own affects alternative to thc. Which means even though both compounds come from the same place they do different things. I believe the individual characters of a few of the different compounds are proven now, IMO CBD is a super drug....rambling lol, anyways.
So here are a few of my thoughts for you from what I have. For the anxiety condition a great CBD compound would probably be good as the CBD its self has more of the say therapeutic aspects to it. It is very calming and creates a nice mellow edge for the body. I'd say in my opinion looking into mj would be an amazing idea, though it may be best to stay away from high doses of thc till the brain is more mature. Low doses in short to slightly prolonged periods would probably be ok, but the high doses from say smoking the plant would probably not be good. From my experience habitual use of thc in under developed minds decreases motor functions, and increased psychosis. Though these affects seem to be decreased if the person starts use after full mental development. I'd really say something down the mj route could work wonders! Not to mention will be much healthier.
Gl2U, May everything work for the best!!!!!!!
Informative stuff.............,
From some of my understanding, the processes and affects the marijuana/hemp plant may have could be limitless as the endocannabinoid system in humans is quite extensive! And as far as symbiotic relationships go, I believe this is one to go in the history books! Since we produce these endocannabinoids we have cannabinoid receptors! Without those, the relationships between the plant and us would be null. The real question now is figuring out where all the receptors are(they could be in every part of our bodies systems), and which different compounds have affects on those certain receptors!
What really peaks my interest is the possibility of certain types of cannabinoid receptors which are expressed in endothelial cells. The endothelial cells line the entire vascular system! Wherever blood flows these cells are! And to make it even more interesting these cells have some duality as, each side of the cell acts as a different lining! They also line the lymphatic vessels, which is very interesting also as the lymphatic system is pretty much a plasma recycling center for our bodies.
All endocannabinoids and plant cannabinoids are fat soluble, compounds. Which means they easily affect the brain as the will pass through the blood brain barrier easily! here is a excerpt from wiki
"There are currently two known subtypes, termed CB1 and CB2.[5][6] The CB1 receptor is expressed mainly in the brain (central nervous system or "CNS"), but also in the lungs, liver and kidneys. The CB2 receptor is expressed mainly in the immune system and in hematopoietic cells.[7]
The protein sequences of CB1 and CB2 receptors are about 44% similar.[10] When only the transmembrane regions of the receptors are considered, amino acid similarity between the two receptor subtypes is approximately 68%.[4] In addition, minor variations in each receptor have been identified. Cannabinoids bind reversibly and stereo-selectively to the cannabinoid receptors. The affinity of an individual cannabinoid to each receptor determines the effect of that cannabinoid. Cannabinoids that bind more selectively to certain receptors are more desirable for medical usage."
CB1
Cannabinoid receptor type 1 (CB1) receptors are thought to be one of the most widely expressed G protein-coupled receptors in the brain. This is due to endocannabinoid-mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission. Endocannabinoids released from the depolarized post-synaptic neuron bind to CB1 receptors in the pre-synaptic neuron and cause a reduction in GABA release.
They are also found in other parts of the body. For instance, in the liver, activation of the CB1 receptor is known to increase de novo lipogenesis.[11] Activation of presynaptic CB1 receptors is also known to inhibit sympathetic innervation of blood vessels and contributes to the suppression of the neurogenic vasopressor response in septic shock.[12]
A study done on CB1 knockout mice (genetically altered mice that cannot produce CB1) showed an increase in mortality rate. They also displayed suppressed locomotor activity as well as hypoalgesia (decreased pain sensitivity). The CB1 knockout mice did respond to Delta9-Tetrahydrocannabinol THC. This shows that either CB2 or unknown cannabinoid receptors also have pharmacologic significance.[13]
CB2
CB2 receptors are mainly expressed on T cells of the immune system, on macrophages and B cells, and in hematopoietic cells. They also have a function in keratinocytes(think rick simpson oil), and are expressed on mouse pre-implantation embryos. They are also expressed on peripheral nerve terminals. These receptors play a role in antinociception, or the relief of pain. In the brain, they are mainly expressed by microglial cells, where their role remains unclear. While the most likely cellular targets and executors of the CB2 receptor-mediated effects of endocannabinoids or synthetic agonists are the immune and immune-derived cells (e.g. leukocytes, various populations of T and B lymphocytes, monocytes/macrophages, dendritic cells, mast cells, microglia in the brain, Kupffer cells in the liver, etc.), the number of other potential cellular targets is expanding, now including endothelial and smooth muscle cells, fibroblasts of various origins, cardiomyocytes, and certain neuronal elements of the peripheral or central nervous systems.[7]
Signaling
Cannabinoid receptors are activated by cannabinoids, generated naturally inside the body (endocannabinoids) or introduced into the body as cannabis or a related synthetic compound.
After the receptor is engaged, multiple intracellular signal transduction pathways are activated. At first, it was thought that cannabinoid receptors mainly inhibited the enzyme adenylate cyclase (and thereby the production of the second messenger molecule cyclic AMP), and positively influenced inwardly rectifying potassium channels (=Kir or IRK).[22] However, a much more complex picture has appeared in different cell types, implicating other potassium ion channels, calcium channels, protein kinase A and C, Raf-1, ERK, JNK, p38, c-fos, c-jun and many more.[22]
Separation between the therapeutically undesirable psychotropic effects, and the clinically desirable ones, however, has not been reported with agonists that bind to cannabinoid receptors. THC, as well as the two major endogenous compounds identified so far that bind to the cannabinoid receptors —anandamide and 2-arachidonylglycerol (2-AG)— produce most of their effects by binding to both the CB1 and CB2 cannabinoid receptors. While the effects mediated by CB1, mostly in the central nervous system, have been thoroughly investigated, those mediated by CB2 are not equally well defined.
