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Re: JG36 post# 66573

Tuesday, 03/12/2013 12:39:16 AM

Tuesday, March 12, 2013 12:39:16 AM

Post# of 146295
Something to think about:
Bacteria constantly remodel their peptidoglycan cell walls, simultaneously building and breaking down portions of the cell wall as they grow and divide. ß-Lactam antibiotics inhibit the formation of peptidoglycan cross-links in the bacterial cell wall; this is achieved through binding of the four-membered ß-lactamring of penicillin to the enzyme DD-transpeptidase. Consequently, DD-transpeptidase cannot catalyze formation of these cross-links, and an imbalance between cell wall production and degradation develops, causing the cell to rapidly die.

So, a little something added to a nanomicelle to disrupt cross-links and essentially a nanoviricide becomes a nanobactericide and potentially can cause the same degradation and death. 75 trillion 20 nm nanobactericides against a billion or so 1 micron bacteria? Like somebody at a nudist camp walking into a killer beehive, only less mobile.

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