Cannabis Science Inc (fka CBIS)

[TinyTitan]

Tis Tis... Why mod the cbis board, which clearly supports the scientific proof that cannabis cures, But yet support novelty products from others??
CBIS has what it takes and you know this!

Cannabinoids, the active components of marijuana and their derivatives, are currently investigated due to their potential therapeutic application for the management of many different diseases, including cancer. Specifically, ?9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) – the two major ingredients of marijuana – have been shown to inhibit tumor growth in a number of animal models of cancer, including glioma.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054795

The Science on Cannabinoids and Cancer
Summary:

Cannabinoids reduce the spread and growth of cancer cells, including breast cancer, oral cancer, colon cancer, and skin cancer.

Cannabinoids disrupt cancer cells’ metastasis and interrupt their usual cell cycle.

Cannabinoids make cancer cells kill themselves, without affecting healthy cells.

Cannabinoids reduce the spread of tumors and can lead to tumor regression.

Cannabinoids used in cancer treatment have no neurotoxic effects.

In no particular order:
(1) Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
Basic info

Published in: Toxicology Letters (November 2012)

http://www.sciencedirect.com/science/article/pii/S0378427412012854

Daiichi University of Pharmacy (Japan)

Hokuriku University (Japan)

Pennsylvania State University (USA)

Quotes
“Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells.”
Meaning
Cannabidiolic acid reduces the spread of breast cancer cells, through a pathway that is already known for reducing the spread of other types of cancer cells.
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(2) Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agent
Basic info

Published in: Best Practice & Research Clinical Endocrinology & Metabolism (Feb 2009)

http://www.sciencedirect.com/science/article/pii/S1521690X09000050

University of Salerno (Italy)

Consiglio Nazionale delle Ricerche (Italy)

Quotes
“[...] predominantly inhibitory effects on tumour growth and migration, angiogenesis, metastasis, and also inflammation have been described. Emerging evidence suggests that agonists of cannabinoid receptors expressed by tumour cells may offer a novel strategy to treat cancer.”
Meaning
Activating the cannabinoid receptors reduces the spread and growth of tumors, suggesting that cannabinoids could be a new way to treat cancer.
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(3) Cannabinoids in intestinal inflammation and cancer
Basic info

Published in: Pharmacological Research (August 2009)

http://www.sciencedirect.com/science/article/pii/S1043661809000838

University of Naples Federico II (Italy)

Quotes
“Studies on epithelial cells have shown that cannabinoids exert antiproliferative, antimetastatic and apoptotic effects as well as reducing cytokine release and promoting wound healing. In vivo, cannabinoids – via direct or indirect activation of CB1 and/or CB2 receptors – exert protective effects in well-established models of intestinal inflammation and colon cancer.”
Meaning
Cannabinoids reduce the spread of cancer cells, disrupt these cells’ metastasis, make cancer cells kill themselves (apoptosis), promote the healing of wounds, and protect the body from inflammation and cancer.
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(4) Cannabinoids attenuate cancer pain and proliferation in a mouse model
Basic info

Published in: Neuroscience Letters (January 2011)

http://www.sciencedirect.com/science/article/pii/S030439401001493X

University of California, San Francisco (USA)

New York University (USA)

Quotes
“When treated with WIN55,212-2 (non-selective), ACEA (CBr1-selective) or AM1241 (CBr2-selective) agonists in vitro, oral cancer cell proliferation was significantly attenuated in a dose-dependent manner. In vivo, systemic administration (0.013 M) of WIN55,212-2, ACEA, or AM1241 significantly attenuated cancer-induced mechanical allodynia. Tumor growth was also significantly attenuated with systemic AM1241 administration. Our findings suggest a direct role for cannabinoid mechanisms in oral cancer pain and proliferation. The systemic administration of cannabinoid receptor agonists may have important therapeutic implications wherein cannabinoid receptor agonists may reduce morbidity and mortality of oral cancer.”
Meaning
Cannabinoids significantly reduce the spread and growth of oral cancer cells.
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(5) Endocannabinoid system modulation in cancer biology and therapy
Basic info

Published in: Pharmacological Research (August 2009)

Quotes
“Emerging evidence suggests that agonists of cannabinoid receptors, which share the useful property to discern between tumor cells and their non-transformed counterparts, could represent novel tumor-selective tools to treat cancer in addition to their already exploited use as palliative drugs to treat chemotherapy-induced nausea, pain and anorexia/weight loss in cancer patients. “
Meaning
Cannabinoids can tell the difference between healthy cells and tumor cells.
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(6) Cannabinoids in the treatment of cancer
Basic info

Published in: Cancer Letters (November 2009)

http://www.sciencedirect.com/science/article/pii/S0304383509002523

University of Otago (New Zealand)

Quotes
“Cannabinoids, the active components of the hemp plant Cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivomodels of cancer. While the various cannabinoids have been examined in a variety of cancer models, recent studies have focused on the role of cannabinoid receptor agonists (both CB1 and CB2) in the treatment of estrogen receptor-negative breast cancer.”
Meaning
Cannabinoids have been shown to have anti-cancer effects in many different experiments.
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(7) Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators
Basic info

Published in: Progress in Lipid Research (January 2013)

http://www.sciencedirect.com/science/article/pii/S0163782712000537

University of Aberdeen (UK)

Strathclyde University (UK)

Quotes
“Cannabinoids-endocannabinoids are anti-inflammatory, anti-proliferative, anti-invasive, anti-metastatic and pro-apoptotic in most cancers, in vitro and in vivo in animals. They signal [...] to induce cell cycle arrest, autophagy, apoptosis and tumour inhibition.”
“Evidence in vivo and in vitro shows EPA and DHA can form endocannabinoids that: (i) are ligands for CB1/2 receptors and possibly TRPV-1, (ii) have non-receptor mediated bioactivity, (iii) induce cell cycle arrest, (iii) increase autophagy and apoptosis, and (iv) augment chemotherapeutic actions in vitro.”
Meaning
Cannabinoids not only reduce the spread and growth of cancer cells but also kill cancerous cells. Cannabinoids stop cancer cells from continuing their usual cycle, tell them to eat each other, tell them to kill themselves, and generally reduce the spread of tumors.
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(8) Cannabis & Cannabinoids
Basic info

Review by the National Institute of Health (USA)

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4

Describes and cites scientific evidence.
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(9) Towards the use of cannabinoids as anti-tumour agents
Basic info

Published in: Nature Reviews Cancer (May 2012)

http://www.ncbi.nlm.nih.gov/pubmed/22555283?dopt=Abstract

Complutense University (Spain)

Quotes
“Various reports have shown that cannabinoids (the active components of marijuana and their derivatives) can reduce tumour growth and progression in animal models of cancer, in addition to their well-known palliative effects on some cancer-associated symptoms.”
Meaning
Cannabinoids can reduce tumor growth.
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(10) Anti-tumoral action of cannabinoids
Basic info

Published in: Nature Medicine (March 2000)

http://www.nature.com/nm/journal/v6/n3/abs/nm0300_313.html

Complutense University (Spain)

Quotes
“9-Tetrahydrocannabinol, the main active component of marijuana, induces apoptosis of transformed neural cells in culture. Here, we show that intratumoral administration of 9-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. Cannabinoid treatment did not produce any substantial neurotoxic effect in the conditions used.”
Meaning
THC makes cancer cells kill themselves. Cannabinoids led to a considerable regression of tumors in rats, but did not lead to neurotoxic effects.
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(11) Gliomas / Cancer
Basic info

Review by NORML (USA)

http://norml.org/library/item/gliomascancer

Describes and cites scientific evidence.
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(12) Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
Basic info

Published in: The Journal of Clinical Investigation (January 2003)

http://www.jci.org/articles/view/16116

Complutense University (Spain)

Clemson University (USA)

Quotes
“In cell culture experiments pharmacological activation of cannabinoid receptors induced the apoptotic death of tumorigenic epidermal cells, whereas the viability of nontransformed epidermal cells remained unaffected. Local administration of the mixed CB1/CB2 agonist WIN-55,212-2 or the selective CB2 agonist JWH-133 induced a considerable growth inhibition of malignant tumors generated by inoculation of epidermal tumor cells into nude mice. Cannabinoid-treated tumors showed an increased number of apoptotic cells. This was accompanied by impairment of tumor vascularization, as determined by altered blood vessel morphology and decreased expression of proangiogenic factors (VEGF, placental growth factor, and angiopoietin 2). Abrogation of EGF-R function was also observed in cannabinoid-treated tumors. These results support a new therapeutic approach for the treatment of skin tumors.”
Meaning

Cannabinoids led to the suicide of skin cancer cells, but did not affect healthy skin cells. Cannabinoids considerably reduced the growth of skin cancer, and prevented the tumor from creating new blood vessels.