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Saturday, February 23, 2013 11:56:19 AM
but I think it is important so I am going to bring it up again. That is the total lack of a survival benefit
found in the Avastin trial for women. Now that lung cancer is the biggest cancer killer of women
this has even more relevance. Here are the numbers from the Sandler et al paper which reported
the Avastin trial results in the NEJM. The MOS overall was 10.3 months in the control arm,
and 12.3 months in the treatment arm.
For the Avastin + CP treatment arm
Male 210 patients (50%), Female 207 patients (50%)
CP control arm
Male 253 (58%), Female 180 (42%)
Subgroup Analysis
Hazard Ratio
Male 0.70, Female 0.98
Median survival control arm
Male 8.7 months, Female 13.1 months
Median survival Treatment arm
Male 11.7 months, Female 13.3 months
A sebsequent paper confirmed this lack of response in women. What is going on here is not clear.
Obviously the MOS for women increased the overall MOS for the trial. Why both the control and
treatment arms for women had a larger MOS, but not different, is the question. It will be very interesting
to see the breakdown for the bavi trial.
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