Hong Yuan Holding Group (HGYN)

[OPKOHEALTH2022]

Proposals: These proposals are fully set forth in the accompanying Proxy Statement, which you are urged to read thoroughly. For the reasons set forth in the Proxy Statement, your Board of Directors recommends a vote “FOR” Proposals 1 and 2. The Company intends to mail the Proxy Statement and Proxy Card enclosed with this notice on or about , 2013 to all stockholders entitled to vote at the Special Meeting. Only stockholders of record at the close of business on February 15, 2013