Biotech Values

[genisi]

The development of anti-drug antibodies has indeed been associated with worse efficacy but also with hypersensitivity reactions, that in very rare cases could result in anaphylaxis and death. This serious systemic reaction is usually quick i.e hours after injection/infusion. Still, when a patient shows hypersensitivity reaction that is getting worse (like the Swedish patient), it is alerting and treatment should be stopped and anti-drug antibodies test should be perform. It's true that usually these anti-drug antibodies don't kill but keep giving the drug to patients with high titre values is harming anyway because the drug isn't working and their condition worsen (increased disability progression, relapse rate, and MRI lesion formation).