Sunday, February 03, 2013 12:32:37 PM
"Before MANF treatment can be considered for clinical applications there are several questions that need to be addressed. Prophylactic treatment capable of dampening the pathological responses to ischemia may be therapeutically important for only small number of patients who are highly prone to ischemic attacks. Before preclinical post-stroke experiments are conducted there are “proof of principle” questions that need to be addressed. Delivery to the intact brain via the ventricular system, vascular system or intranasal route needs further development. The increased permeability of blood brain barrier (BBB) after the onset of stroke, provides a window to target ischemic brain tissue for compounds that normally do not cross BBB. Other problems that need to be studied include the ability of post-stroke MANF delivery to promote recovery, timing of administration after stroke, and efficacy of coadministration of MANF with other treatments, like physical therapy or exercise, to promote recovery. Also, pre-clinical studies of MANF in other animal models of ischemic brain injury are needed. After these issues are addressed, safety, tolerance and efficacy of delivery should be evaluated in humans. Ultimately, a clinical study in a small number of stroke patients could be considered."
ELEMENT79 ANNOUNCES UPLISTING TO OTCQB VENTURE MARKET • ELMGF • Aug 26, 2024 10:03 AM
North Bay Resources Announces Gold Assays up to 2.2 Ounces per Ton, Fran Gold Project, British Columbia • NBRI • Aug 26, 2024 10:00 AM
PickleJar Unveils Latest Venue Managed Services Innovations in Upcoming Webinar • PKLE • Aug 23, 2024 1:11 PM
Element79 Gold Corp Provides Update on Nevada Portfolio • ELMGF • Aug 23, 2024 8:00 AM
Maybacks Adds Award Winning Show to Its Lineup Discusses Maybacks Opportunity • AHRO • Aug 22, 2024 11:30 AM
North Bay Resources Announces First Gold Concentrate at Mt. Vernon Gold Mine, Assays 12 oz/ton Gold, 17.5 oz/ton Platinum, and 8 oz./ton Silver, Sierra County, California • NBRI • Aug 22, 2024 10:28 AM