Thursday, January 31, 2013 11:27:21 AM
from page 7:
"...one can conclude that agents irrespective of their level of in vitro activity which have activity in less than 33% of [mouse] models tested had no "positive" phase 2 clinical trials. In contrasts, agents with activity in at least 33% of such models had an approximately 50% likelihood of positivity in phase 2 clinical trials."
Hmm, I wonder what the likelihood of positive phase 2 results is in an agent with activity in 100% of the mouse models tested.
A1
Tumor Models in Cancer Research
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