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biocqr

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biocqr

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Re: None

Friday, 01/18/2013 8:40:16 AM

Friday, January 18, 2013 8:40:16 AM

Post# of 252969
David Grainger @sciencescanner
Chance finding of v elevated cholescytokinin (CCK) in patient with parasitic worms reveals weight loss mechanism:

http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003122

David Grainger @sciencescanner
CD4+ T cells induce CCK production by l-cells in the gut during enteritis, leading to loss of appetite, hypophagy and weight loss...

David Grainger @sciencescanner
… with altered leptin levels feeding back to modulate the immune system and improve the rate of clearance of the worms. Fascinating

David Grainger @sciencescanner
Suggests CCK receptor agonists may have important new roles in obesity AND immunomodulation. Was that the sound of a starters gun?
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