Avid Bioservices Inc (CDMO)

[freethemice]

I wrote about anti-PD-1 and anti-CTLA-4 previously. Can't seem to find the link right now. I expect the side
effects are worse than bavi and won't work as well since they are both downstream in the immune
response pathway from where bavi works. That is, they are both directed to work in the adaptive part of the
immune response which depends on the innate part to get things started. I don't think they will do anything
to reverse the immunosuppression that limits the effectiveness of the adaptive response, or to switch
macrophages from the pro-tumor M2 type to the anti-tumor M1 type. Anti-CTLA-4 has worked well in melanoma,
but bavi might work better. It is too early to tell much about anti-PD-1 and anti-PD-L1.