Celsion Corporation (CLSN)

[kris_kade]

Pegylated liposomal doxorubicin vs lysolipid thermally sensitive liposomes aka TDOX




The unnamed source for the 'hit job' story by Adam F, argues that the Thermodox trial will fail because a previous liposomal trial failed.

"A 2011 study published in Hepatology International (Jing-Houng, et al.) showed pegylated liposomal doxorubicin administered intravenously in conjunction with RFA had no beneficial impact on tumor progression or survival compared to RFA alone."

Now from what I understand, the huge difference with TDOX lipsomes is targeted delivery of very high concentrated doxorubicin.

This difference would make or break HEAT trial, IMHO..

Any thoughts from bio gurus out there would be highly appreciated