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Re: Rawnoc post# 6781

Sunday, 01/06/2013 6:01:09 PM

Sunday, January 06, 2013 6:01:09 PM

Post# of 16750
"(2) Mgmt NEVER said to "expect 12 months PFS" -- YOU did. You cannot show me a single link, image, CC quote, absolutely NOTHING that says 12 months and PFS. You're still running around in circles with the local recurrence only estimate that has NEVER been expressed as a PFS estimate by management. Just you."

In the first link you provided, the 2Q12 cc (http://seekingalpha.com/article/807791-celsion-management-discusses-q2-2012-results-earnings-call-transcript?part=single)
in MT's opening remarks he says,

"In our target population, median time to progression is 12 months with median time to death 30 months"

Pretty clear he says "our target population" - you agree that will be the HEAT population?

He does say TTP and not PFS. Since he does NOT break out local vs distant, that has to be meant as mgmt's assumptions FOR THE HEAT POPULATION.

TTP does not include death. But since death should occur after progression, using TTP as a proxy within the trial should be fine for our purposes.
IOW, if TTP (which is local AND distant) is 12 months, and death is 30 months, you are safe to say 12 months at best. It probably will be longer than that.

I repeat, yes the term used was TTP and you seemingly want to find an exact quote for PFS. But I fail to see how a worse TTP than other-event time can cause TTP to be less than 12.