Celsion Corporation (CLSN)

[sdtrond]

I agree with some caution on your points.

RFA alone *is* curative.

In other words, if the ablation is successful, the patient walks out of the clinic with no (detectable) cancer.

As we all know, it is in the margins of the ablation zone that some micromets or actual tumorous tissues remain. And if those are not caught on the follow up visit, then those patients will almost certainly recur and pretty darn soon.

Adding TDox is 3x the ways effective. It lowers the surrounding temperature, making the ablation more effective. Heat increases the effectiveness of dox. And the dox obviously also helps kill cancer (and healthy) cells.

So either arm, if it doesn't happen in 12 months, it won't for QUITE awhile.

Agree on first line use with all RFA.

My second largest quibble with "much less" than 12 months (again #1 is getting the timeline to work with enrollment and interim/final event dates) that that we have an SPA. No way FDA would have given us such a free pass as to softball the placebo PFS. They work with the same data and trying to get 80% powered with 33% improvement ... just won't happen at <11 months or so.