Here are the Scientific Publications on
MANF
these are on the website.. Most Important part... AMBS has the PATENTS
Oh-Hashi K, Tanaka K, Koga H, Hirata Y, Kiuchi K (2012). Intracellular trafficking and secretion of mouse mesencephalic astrocyte-derived neurotrophic factor. Mol Cell Biochem. 363: 35-41.
Niles LP, Sathiyapalan A, Bahna S, Kang NH, Pan Y. (2011) Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain. Int J Neuropsychopharmacol 16: 1-8.
Hellman U, Arumäe U, Yu L, Lindholm P, Peränen J, Saarma M, Permi P (2011) Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons . J Biol Chem 286:2675-2680.
Voutilainen MH, Bäck S, Peränen J, Lindholm P, Raasmaja A, Männistö PT, Saarma M, Tuominen RK. (2011) Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson’s disease. Exp Neurol. 228: 99-108.
Glembotski CC (2010) Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure. J Mol Cell Cardiology, In Press
Hellman U, Peränen J, Saarma M, Permpanich B (2010) (1)H, (13)C and (15)N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor. Biomol NMR Assign 4:215-217.
Airavaara M, Chiocco MJ, Howard DB, Zuchowski KL, Peränen J, Liu C, Fang S, Hoffer BJ, Wang Y, Harvey CA (2010) Widespread cortical expression of MANF by AAV serotype 7: Localization and protection against ischemic brain injury. Exp Neurol 225:104-113.
Lindholm P, Saarma M (2010) Novel CDNF/MANF Family of Neurotrophic Factors. Dev Neurobiol 70:360-371.
Voutilainen M, Back S, Porsti E., Toppinen L, Lindgren L, Lindholm P, Peranen J, Saarma M and Tuominen R (2009). Mesencephalic Astrocyte-derived Neurotrophic Factor is Neurorestorative in a Rat Model of Parkinson’s Disease. J Neurosci, July 29, 2009. 29(30):9651–9659.
Yong-Qiang Yu1, Lian-Cheng Liu1, Fa-Cai Wang2, Yan Liang2, Da-Qin Cha2, Jing-Jing Zhang2, Yu-Jun Shen2, Hai-Ping Wang2, Shengyun Fang2,3 and Yu-Xian Shen2 (2009). Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection, J CBFM Sept 23: 1–13
Airavaara M, Shen H, Kuo C-C, Peränen J, Saarma M, Hoffer B, Wang Y (2009) Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats. J Comp Neurol 515: 116-124.
Parkash V, Lindholm P, Peranen J, Kalkkinen N, Oksanen E, Saarma M, Leppanen VM, Goldman A (2009). The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. Protein Engineering Design Selection 22: 233-24.
Palgia M, Lindstrom R, Peranen J, T. Piepponen P, Saarma M, Tapio I. Heino TI (2009) Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons. PNAS 106: 2429–2434.
Tadimalla A, Belmont PJ, Thuerauf DJ, Glassy MS, Martindale JJ, Gude N, Sussman MA, Glembotski CC (2008) Mesencephalic Astrocyte-Derived Neurotrophic Factor Is an Ischemia-Inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart. Cir Res 103: 1249-1258.
Lindholm P, Andressoo J-O, Kalkkinen N, Kokaia Z, Lindvall O, Timmusk T, Peranen J, Saarma M (2008). MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain. Mol Cell Neurosci 39: 356-371
Apostolou A, Shen Y, Liang Y, Lou Y, Fang S. (2008) Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. Exp Cell Res 14: 2454-2467.
Mizobuchi N, Hoseki J, Kubota H, Toyokuni Y, Nozaki K, Naitoh M, Koizumi A, Nagata K. (2007) ARMET is a Soluble ER Protein Induced by the Unfolded Protein Response via ERSE-II Element. Cell Struct Funct 32: 41-50.
Zhou C, Xiao C, Commissiong JW, Krnjevic K, Ye JH. (2006) Mesencephalic astrocyte-derived neurotrophic factor enhances nigral [gamma]-aminobutyric acid release. NeuroReport 17: 293-297.
Petrova PS, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire A, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW. (2004) Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases. Prog Brain Res 146: 168-183.
Petrova PS, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW. (2003) MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. J Mol Neurosci 20: 173-188.
PhenoGuard Protein Discovery Engine
Takeshima T, Johnston JM, Commissiong JW (1994) Mesencephalic type-1 astrocytes rescue dopaminergic neurons from death induced by derum-deprivation. J Neurosci 14: 4769-4779
Panchision D., Martin-DeLeon P, Takeshima T, Johnston J, Shimoda K, Tsoulfas P, McKay R, Commissiong JW (1998). An immortalized Type-1 Astrocyte Origin of a Dopaminergic Neurotrophic Factor. J Mol Neurosci. 11-208-221
Takeshima T., Shimoda K. Johnston J.M., Commissiong J. (1996). Standard methods to bioassay neurotrophic factors for dopaminergic neurons. J Neurosci Meth 67: 27-41
