Viral Treatments Halt Growth in Metastatic Tumors
News from Cancer Discovery Jan. 2013
Thanks kinaseman from V2:
January 3rd issue of Cancer Discovery - The journal of the AACR
Viral Treatments Halt Growth in Metastatic Tumors
Abstract
Preliminary results from a phase III clinical trial showed that a combination of the anticancer viral treatment Reolysin and chemotherapy was more effective at halting metastatic tumor growth than chemotherapy was alone.
A combination of anticancer viral treatment and chemotherapy was more effective at halting metastatic tumor growth than chemotherapy was alone, according to preliminary results from a phase III clinical trial in patients with head and neck cancers, announced by Oncolytics Biotech of Calgary, Alberta, Canada, in
December.
"To the best of our knowledge, this is the first successful double-blinded randomized data from a clinical study using an intravenously administered oncolytic virus," said Brad Thompson, PhD, chief executive officer of Oncolytics.
Known as Reolysin, the Oncolytics treatment is a reovirus similar to that which causes the common cold. Engineered reoviruses, such as the Oncolytics therapeutic, exploit the antiviral immunity defects that tend to accumulate in cancer cells. Moreover, Reolysin can only survive and replicate in cancer cells with an activated RAS pathway, said Matt Coffey, PhD, Oncolytics chief operating officer, who led early studies of reoviruses as potential anticancer agents.
Eventually, cancer cells become packed with so many viral particles that they burst and die, Coffey explained. But because normal cells lack activated RAS, they avoid a similar fate after viral treatment.
In the ongoing study, 167 patients with advanced head and neck cancers are receiving either carboplatin and paclitaxel followed by Reolysin, or the chemotherapy agents only. Reolysin doses amounting to an estimated 1 trillion viral particles were administered intravenously once a day for 5 consecutive
days.
The current results apply only to a subset of 105 patients with metastatic tumors in the liver, lungs, or lymph nodes. Six weeks after treatment, 86% of those patients treated with Reolysin had achieved metastatic tumor stabilization or shrinkage, compared with 67% of control patients who did not receive viral therapy. Side effects were limited to minor flu symptoms.
Results for the entire cohort, including patients who do not have metastatic disease, will be presented at a later date, Coffey said.
Oncolytics conducted the subset analysis after a preliminary assessment revealed that patients with metastatic illness had achieved more substantial improvements in progression-free survival (PFS) after Reolysin treatment than did patients whose primary tumors had not metastasized. Given those findings, a review panel at the U.S. Food and Drug Administration (FDA) recommended that Oncolytics evaluate Reolysin's effects specifically on metastasized tumors.
The difference in PFS between patients with or without metastatic illness makes sense, Coffey said, because metastatic tumors tend to have better circulation—and therefore better access to viral particles—than do their corresponding primary malignancies.
"Moreover, activated RAS drives the metastatic phenotype," Coffey said. "Because of that, metastatic tumors are particularly homogenous with respect to RAS activation and that makes them uniquely responsive to treatment."
More than a dozen clinical trials are under way for Reolysin. Positive preliminary results in phase II trials for non–small cell lung cancer and pancreatic cancer were reported in November at the 2012 Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland.
Although viral treatments for cancer have been studied for many years, none has been approved by the FDA. One other likely contender is Amgen's OncoVEX, which has been evaluated as a treatment for melanoma in a phase III trial whose results have not yet been announced.
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