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Just a Few More....MANF's...!!...



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Valproic acid up-regulates melatonin MT1 and MT2 receptors and neurotrophic factors CDNF and MANF in the rat brain.
Int J Neuropsychopharmacol, October 2012


Intracellular trafficking and secretion of mouse mesencephalic astrocyte-derived neurotrophic factor.Recently, mesencephalic astrocyte-derived neurotrophic factor (MANF) has been reported to prevent cell death under some pathophysiological conditions. ...
Mol Cell Biochem, April 2012


Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease.... disease (PD). Mesencephalic astrocyte-derived neurotrophic factor (MANF) belongs to a novel evolutionarily conserved family of neurotrophic ...
J Neurosci, July 2009


Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion.... (ER) stress protein mesencephalic astrocyte-derived neurotrophic factor (MANF) has been reported to protect cells from stress-induced cell death before ...
J Biol Chem, July 2012


Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats.Mesencephalic astrocyte-derived neurotrophic factor (MANF), also known as arginine-rich, mutated in early stage of tumors (ARMET), is a secreted protein ...
J Comp Neurol, July 2009


Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease.... factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) constitute a novel, evolutionarily conserved family of neurotrophic ...
Exp Neurol, March 2011


1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor.... discovered NTFs mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF) most efficiently ...
Biomol NMR Assign, October 2010


Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.... neurotrophic factor in Drosophila, DmMANF, homologous to mammalian MANF and CDNF. DmMANF is expressed in glia and essential for maintenance of ...
Proc Natl Acad Sci U S A, February 2009


CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment in Mice.... discovered protein, which belongs to the evolutionarily conserved CDNF/MANF family of neurotrophic factors. The degeneration of dopamine neurons ...
Cell Transplant, January 2012


Neurorestoration.... as describe more recent studies with two newly described trophic proteins, MANF and CDNF. Data will be presented from various animal models of PD ...
Parkinsonism Relat Disord, January 2012


Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart.... genes, including mesencephalic astrocyte-derived neurotrophic factor (MANF). In the present study, MANF expression was shown to be induced in cardiac ...
Circ Res, November 2008


Mesencephalic astrocyte-derived neurotrophic factor enhances nigral gamma-aminobutyric acid release.Mesencephalic astrocyte-derived neurotrophic factor (MANF) - one of a new class of astrocyte-derived human proteins--selectively promotes the survival of ...
Neuroreport, February 2006


Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death.... microarray analysis. Here, we describe characterization of Armet/MANF, one of the 12 genes whose function was not clear. We demonstrated that ...
Exp Cell Res, August 2008


Neurotrophic factors and Parkinson's disease: the emergence of a new player?... application of this treatment strategy. The identification of CDNF and MANF, which constitute a new class of neurotrophic factors active against ...
Sci STKE, November 2007


Discovering novel phenotype-selective neurotrophic factors to treat neurodegenerative diseases.... lines (VMCL1). This mesencephalic astrocyte-derived neurotrophic factor (MANF) is a 20 kD, glycosylated, human secreted protein. Homologs of this ...
Prog Brain Res, January 2004


Gene cloning, DNA sequencing, and expression of thermostable beta-mannanase from Bacillus stearothermophilus.... blue-locust bean gum. The nucleotide sequence of the mannanase gene, manF, corresponded to an open reading frame of 2,085 bp that codes for a ...
Appl Environ Microbiol, November 1998


Effect of 2, 3, 4, 7, 8-pentachlorodibenzofuran and its analogues on induction of sister chromatid exchanges in cultured human lymphocytes.... in terms of the concentration of TCDD toxic equivalent. 2) 8 x 10(-5) MANF significantly enhanced the frequency of SCEs and the simultaneous ...
Fukuoka Igaku Zasshi, May 1995