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Re: joboggi post# 26284

Monday, 12/24/2012 5:15:48 PM

Monday, December 24, 2012 5:15:48 PM

Post# of 130505
Absolutely...MANF is known to deliver better to the brain than due to a variety of reasons but primarily due to the structure of the protein. I can send you some publications on it or you can just google MANF publications and read up on it. GDNF was halted (it's back in stage 2) because it dispersed too widely when it entered the cranium upon injection, rendering a placebo effect and also because delivery methods were poor. Delivery methods have been vastly improved since GdNF was halted (which is why Prof Gill at bristol Univ has brought it back for trials) and MANF's dispersion characteristics are much more favorable.