Monday, December 24, 2012 3:09:52 AM
While I can't address your questions regarding the specific mechanisms of actions of Kevetrin (I will look into this, however), I did want to say a couple important points.
There is NO drug out there to which we know full mechanisms of actions. Not even close. That includes Aspirin. Indeed we know the mechanisms by which it is beneficial, but that does not mean we know all of its mechanisms. Anti-depressants were discovered by complete accident - in fact the first drug was not even intended for psychiatric disorders... it was only after patients showed mood improvement did we find out the first begin to look into why this compound was causing mood improvement. There are tons more examples - a modern one being Memantine, an anti-alzheimer's drug that is actually showing promise for other cognitive issues, particularly OCD. Plenty more mechanisms are being discovered other than it being an NMDA receptor antagonist.
If Kevetrin was initially thought to work in one way, and found to work in another... that is no reason to be weary of the compound. Believe me when I say some of the most important discoveries in the history of science have been made by sheer accident. Sooner or later, scientists will develop profound humility for the complexity that we are. That does not mean they give in, it simply means when something is revealed accidently, it will often be similar to receiving a great gift of potential insight.
I need to re-visit my molecular bio book and look at some of these pathways that are cloudy to me atm. I do recall ubiquitin is involved in key pathways that allow the cell to know whether a protein needs to be tossed in the trash because it's not folding as it should. Alterations in the ubiquitin could be the means by which mutant p53 takes over since it cannot be tagged as a mutant. This is purely hypothesis - it's been years, and as I said I have not looked into the mechanisms regarding Kevetrin in great detail.
"A man should look for what is, and not for what he thinks should be." -Albert Einstein
Call me RD.
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