Avid Bioservices Inc (CDMO)

[freethemice]

Is this a sign of things to come with Bavi and SBRT?
A Systemic Complete Response of Metastatic Melanoma to Local Radiation and Immunotherapy
Translational Oncology, Vol 5, issue 6, 2012
FREE: http://www.transonc.com/abstract.php?msid=351
Abstract
Background: Melanoma is a relatively immunogenic tumor, in which infiltration of melanoma cells by T lymphocytes is associated with a better clinical prognosis. We hypothesized that radiation-induced cell death may provide additional stimulation of an anti-tumor immune response in the setting of anti-CTLA4 treatment. Methods: In a pilot melanoma patient, we prospectively tested this hypothesis. We treated the patient with two cycles of ipilimumab, followed by stereotactic ablative radiotherapy to two of seven hepatic metastases, and two additional cycles of ipilimumab. Results: Subsequent PET-CT scan indicated that all metastases, including un-irradiated liver lesions and an un-irradiated axillary lesion had completely resolved, consistent with a Complete Response by RECIST. Conclusion: The use of radiotherapy in combination with targeted immunotherapy as a non-invasive in vivo tumor vaccine strategy appears to be a promising method of enhancing the induction of systemic immune responses and anti-tumor effect.