Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Regis999]

Some history on Anatabloc in this Testimony:

One of the most interesting posts on the background of Anatabloc.


Anatabloc nutraceutical supplement at GNC or online at

https://store.anatabloc.com/node/1


Source
http://supplement-geek.com/anatabloc-anatabine-inflammation-review/


Justme

December 20, 2012 at 4:05 pm

Joe:

As one with a great deal of experience with this product, and one who has thoroughly researched the companies and research organizations behind it, I have reams to say but, alas, only moments right now to comment.

Let me take two things to address quickly (guess it turned into three).

First I would like to comment on your continuing comments to the effect …

++++++++++ quote

i find it ironic that they would release a supplement to the market based on 2 mouse studies an an as of yet not complete human trial.

but when TV commercials say it works for joints and muscles – but have no evidence to base those claims – then you need to know that

Ben, the only way to truly know something is to look at the research conducted on the product. Anatabloc TV commercials are saying that its proven to reduce inflammation in joints in muscles but I see none of that proof they are talking about.

++++++++++ end quote



I think you are overlooking (or unaware of) the route to discovery of the anti-inflammatory effect of anatabine. Those many hundreds of us “first adopters” of an anatabine supplement, made by the same company prior to Anatabloc and intended for another purpose NOT RELATED to issues of inflammation and pain resulting therefrom, were “the ones” who discovered the property (along with the researchers who tried the substance and had the same kinds of results at the same time).

They and we all began comparing notes (in online forums), with a feeling of embarrassment for many of us who were not really sure whether to believe, or not, what we experienced, and thus were we glad to hear others report and confirm the same.



After much preliminary research on dose and safety with a totally new direction in mind for a new product based on this evidence, the research staff at Rock Creek, in cooperation with the researchers, brought the product to market as a supplement based on THAT evidence … the reports of hundreds of individuals, many thousands by now (but we first adopters had NO reason to expect any such result), who on their own initiative reported that a new supplement marketed as an aid to reduce smoking was actually doing wonders for a very wide variety of “inflammatory issues”.

“The evidence” is that, probably more than anything else, we reported results from helpful to dramatic (but NOT “curative”) for arthritic and other joint pain. The only thing I know of that we experienced to a similar degree was rapid chronic sinusitis help, and the company apparently thought the joint pain relief to be something more solid or significant.

That said as to what we most reported, many many of us reported help not only with joint pain and sinusitis but with (likely number 3) asthma, benign prostatitis (BPH) … on and on, with some reporting relief of such serious things as, especially, Crohn’s and RA.

Again I emphasize that none of us had any reason to expect any such results. However, the researchers involved took the matter seriously, and as soon as their subsequent research began to leak out about why this may be, “things” began to come together to complete the picture. It turned out that this may be the first almost side-effect-free substance that avoids the mixed bag of results caused by “shotgun” anti-inflammatories like NSAIDS and even steroids because it much more directly works on a major inflammatory mechanism called NF-kB.

And so it turns out that what all these conditions have in common is NF-kB … and, if one thinks about it, “autoimmunity”. Another of these is Hashimoto’s thyroiditis … but the promise here would be (in my estimation) one of prevention, as this long term illness develops over decades (usually) due to attack of one’s thyroid by one’s own antibodies. Thus the thyroid studies.

But the significance here is how what I just reported unfolded: in reverse order from the usual “drug development path”. It was not that a pharmaceutical company looked for an NF-kB modulator because of the connection of that with a host of disorders, found it, and then tested it for efficacy, etc. The significance is that this all happened in reverse order. Thus there was no (initial) impetus for a drug company to get benefit from millions of dollars of research (having found an NF-kB modulator) by crafting carefully designed (and limited) studies to prove benefit, all the while hoping that the side effects would prove to not be “too bad”.

“The studies” happened without expectation, regarding a product that had a stated design for an entirely different and unrelated purpose. I believe that we are so unused to such an event happening in short order (rather than in a progression of hundreds or thousands of years of “folk medicine”, such as with the still-amazing properties of salicylates [aspirin, from tree bark]) that we find it difficult to understand the significance of such events.



You are, I believe, tending to dismiss “the evidence” because you are used to not believing individual reports of success with some product that (the success of which for some already-defined purpose) may be EXPECTED by the user … the placebo effect. If you consider how this all happened, I think you will realize that your perspective on this issue is skewed by your normal response and expectations to a different, and usual, set of circumstances. This is “the usual” in, more or less, reverse order, and thus NOT “the usual”.

The epidemiological evidence cited, by the way, has to do with studies done on those exposed to second-hand smoke (which contains about 3% anatabine of total alkaloid content, mostly nicotine). A group wanted to prove that, among other things, such exposure had a negative effect on the thyroids of those thus exposed. Their finding, to their dismay, was the opposite, and it apparently turns out that the anatabine in the smoke is the likely reason.

I must go but I must say quickly that I don’t know where all these strange addresses for Rock Creek came from, but the correct address is on every product: 55 Blackburn Center, Gloucester, MA. It is true that the company is small and has only been there about 3 years. It’s not a big factory, but in their small space Dr. Wright and his small team have done some marvelous things.

I will come back when I have time, but that may be mid spring.

I am not an employee of any company or research organization. I am a retired scientist and a great benefactor of this amazing set of circumstances. It has literally made my life worth living again, having been set upon by what I now recognize was a sudden and vicious rash of autoimmune disorders, probably foretold by my lifelong Hashimoto’s and asthma (a likely hint at an autoimmune tendency, I now realize). By the way I did not start the original supplement in relation to a smoking habit.

I am a stockholder. I hope I do not sound as though I know “too much”, although truthfully, due to my own intensive research, I may know as much as anyone else outside the company about it. I don’t know whether to apologize for that or to celebrate it, in light of some things said in other comments, but I feel more celebratory, personally. I hope my research has not rendered me to be someone to not be taken seriously.

I DO wish I had more time right now.

PS: Another thing, quickly. Those who are tobacco naive especially, but probably all, should start taking this SLOWLY, one tab every day or two (or even a half) and work up over a period of say three weeks. One’s chances of noticeable side effects are hugely reduced in such a case, and very very few should have any serious enough to prevent taking it continuously as a preventive as well as a treatment … another novelty for “anti-inflammatories”.



PPS: For those who may worry about the MAOI property, it is unique (shared with other minor tobacco alkaloids nornicotine and anabasine) in that it, somehow, self-limits to a safe level. One can learn about this by reading the older patents which presumed that the active aspect would be this property (to aid in reducing smoking, for example) … for example Patent 6,569,470. Indeed the now many patents that relate to these developments are very revealing and a good source of information.



JoeDecember 20, 2012 at 4:52 pm



JustMe, I appreciate you writing all that you did. I’m curious what the original use for anatabine was? As a retired scientist I’m sure you can appreciate my need for human peer reviewed research on Anatabloc. In the world of supplements there is so much talk of testimonials and vague claims of being “clinically proven.” While I do not discount voices like yours who say anatabloc has helped them, I do, when I can, try to make peer reviewed human research my litmus test for products.



Again, really appreciate you taking the time for writing.



There are over 130 testimonials on the GNC for Anatabloc. See http://www.gnc.com/product/index.jsp?productId=12629596&kwCatId=#showReviews