mcbio those numbers berger sites are for 2nd and 3rd line imho.Jq cited concerns about 1st and 2nd line use though, at least initially. Perhaps ARIA will be successful in those lines in due time. one very good analyst that called approval in december has pona estimates of 3 billion in 2020.Thanks. Just like to hear some more chatter about peak sales estimates as I haven't heard much.